Sunday, June 18, 2006

Endothelial Inflammation as Reation to Medications

Diabetes Care 29:291071-1076, 2006 had two articles on endothelial function and inflammatory marker response to two medications in the TDZ (thiazolidinedione) class that has been used to treat diabetes 2.

Now that there is more understanding of those who have no insulin on stimulation – therefore looking like diabetes type 1- can non-the-less be benefited by the use of these drugs, this information applies to those with type one and type two. The accelerator theory is useful in all sorts of ways.

The endothelium is a layer of thin, flat cells that line the interior surface of blood vessels, forming an interface between circulating blood and the rest of the vessel wall.

Inflammation is the body's response to injury. The markers include mediators and inhibitors of inflammations and potentially dangerous substances such as toxins.

Both Actos and Avandia had positive effects on the endothelium which means they were likely not only to improve the insulin sensitivity but prevent heart attacks, strokes and prevent all other manner of cardiovascular disease and small vessel disease. It’s your time.

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